棉酚的抗生育作用,近年来已有大量报道,本实验是观察服棉酚过程中垂体远侧部的组织学变化及停药后的恢复情况,借以为棉酚的避孕机制及毒副作用提供参考资料。材料及方法用体重39.5～55.5公斤雄性阉猪九只,其中两只(6、9号)为对照组,7只为实验组(2～5、7、8、10号),喂以中国医学科学院药物研究所精制的醋酸棉酚,生活条件两组无异。投药前,实验动物先饲养五天,观察其行为、饮食等均属正常,随即用口服法投药30 The anti-fertility effect of gossypol has been widely reported in recent years. This experiment is to observe the histological changes in the distal part of the pituitary during the administration of gossypol and recovery after discontinuation, in order to provide the contraceptive mechanism and side effects of gossypol. Reference materials. Materials and Methods Nine male body weight pigs weighing 39.5 to 55.5 kg were used, of which two (6 and 9) were control groups and 7 were experimental groups (2-5, 7, 8 and 10). They were fed with Chinese medicine. The Academy of Pharmaceutical Sciences refined Gossypol acetate, living conditions are the same for both groups. Before the administration of the drug, the experimental animals were kept for five days and their behavior, diet, etc. were observed to be normal, and they were administered orally.