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设计一项前瞻性随机对照临床研究，比较了术前口服联合围手术期静脉给药途径与单一的术前口服给药途径在结、直肠癌手术中的预防效果。２４例结、直肠癌患者被随机分为２组。（１）口服组术前２ｄ每日口服庆大霉素和甲硝唑；（２）联合组除接受上述口服给药方案外，还与围手术期静脉滴注相同的抗菌药物。对肠道细菌进行定量培养，证实了术前口服庆大霉素和甲硝唑使肠道内需氧菌和厌氧菌的数量明显减少。还对围手术期血清和手术期间组织中庆大霉素和甲硝唑的浓度进行测定，口服组在手术期间血清和组织中甲硝唑均达有效浓度，但庆大霉素未能测出；联合组在手术期间血清和组织中两药均达有效浓度。结果提示，术前口服联合围手术期静脉给药途径较为合理。
A prospective, randomized, controlled clinical study was designed to compare the preventive effect of oral preoperative perioperative intravenous route with single preoperative oral route of administration in colorectal cancer surgery. Twenty-four patients with colorectal cancer were randomly divided into two groups. (1) Oral gentamycin and metronidazole were given daily 2 days before surgery; (2) In addition to the above-mentioned oral dosing regimen, the combined group also had the same antibacterial agent as perioperative intravenous drip. Quantitative culture of intestinal bacteria confirmed that preoperative oral administration of gentamicin and metronidazole significantly reduced the number of aerobic and anaerobic bacteria in the gut. The concentration of gentamicin and metronidazole in the perioperative serum and tissue during the operation was also measured. In the oral group, metronidazole reached an effective concentration in serum and tissue during the operation, but gentamicin was not detected. Both groups achieved effective concentrations in both serum and tissue during the surgery. The results suggest that the preoperative oral administration combined with perioperative intravenous route is more reasonable.