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实验观察1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基乙胺基)丙烷盐酸盐(简称DDPH)对低氧大鼠肺动脉高压(HPHT)和腺泡内肺动脉(IAPA)构形重组的影响.结果表明,在缺氧后期和常氧恢复期使用DDPH的大鼠右心室收缩压(RVSP)分别比未用药组降低18.98%和17.85%;右心室肥大指数(RVHI)分别减小18.18%和12.50%;腺泡内环肌型动脉数量减少、中膜厚度变薄;无肌型动脉数量增多、管径明显扩大(P<0.05).肺动脉收缩压的改变与腺泡内血管构形的改变密切相关(R~2=0.9865,P<0.01).提示DDPH对HPHT的形成和IAPA构形重组具有阻抑和逆转效应.
The effect of 1- (2,6-dimethylphenoxy) -2- (3,4-dimethoxyethylamino) propane hydrochloride (abbreviated as DDPH) on pulmonary hypertension (HPHT) (IAPA) were measured by real-time PCR.The results showed that right ventricular systolic pressure (RVSP) decreased by 18.98% and 17.85% in DDPH rats during hypoxia and normobaric convalescence respectively, Right ventricular hypertrophy index (RVHI) decreased by 18.18% and 12.50%, respectively. The number of medial acinar artery decreased and the thickness of medial membrane became thinner. The number of non-muscular artery increased and the diameter increased significantly (P <0.05) The change of systolic pressure was closely related to the change of angiogenesis in the acinus (R ~ 2 = 0.9865, P <0.01), suggesting that DDPH can suppress and reverse HPHT formation and IAPA conformational remodeling.