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为探讨氟铝联合对大脑神经细胞的毒作用及其机制，采用无血清体外细胞培养方法，观察氟铝对人胚大脑神经细胞生长发育及功能的影响，同时进行光镜和电镜形态学观察。结果显示高剂量铝（１０μｍｏｌ／Ｌ）可以抑制大脑神经细胞的生长发育，引起大脑神经细胞超微结构的损害表现为各种膜结构的损害及神经微丝微管排列紊乱。在本研究剂量范围，加入不同剂量的氟并未对铝的损伤作用产生明显的影响，说明本研究剂量的铝氟不存在拮抗或协同作用。
In order to explore the toxic effect and mechanism of fluoride-aluminum combined on cerebral nerve cells, serum-free in vitro cell culture method was used to observe the effects of fluoride and aluminum on the growth and function of human embryonic brain cells. Morphological observation under light and electron microscopes was also performed. The results showed that high dose aluminum (10μmol / L) could inhibit the growth and development of nerve cells in the brain. The damage of the ultrastructures of the brain cells was caused by the damage of various membrane structures and the disordered arrangement of the neurofilament microtubules. In the study dose range, adding different doses of fluorine did not have a significant impact on the role of aluminum damage, indicating that the dose of aluminum fluoride does not antagonize or synergistic effect.