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目的:探讨中药黄连和厚朴药的不同提取方法对小鼠小肠功能的影响。方法:观察黄连、厚朴不同提取方法对小鼠小肠推进功能的影响、对番泻叶致小鼠腹泻模型的影响,液体试管法观察体外抑菌作用。结果:黄连和厚朴分别用乙醇提取再合并的提取方法能够显著抑制小鼠小肠炭末推进率(P<0.01),缓解番泻叶所致小鼠腹泻(P<0.01),对大肠杆菌、绿脓杆菌、金黄色葡萄球菌等试验菌的抑制作用强于黄连厚朴共同用乙醇提取。结论:黄连厚朴分别醇提后再合并的提取方法对小鼠小肠功能的影响最为显著。
OBJECTIVE: To investigate the effects of different extraction methods of Coptis chinensis and Magnolia officinalis on mice’s small intestine function. Methods: The effects of different extraction methods of Coptis chinensis and Magnolia officinalis on the intestinal propulsive function of mice, the effect of senna-induced diarrhea model in mice, and the in vitro antibacterial effect of liquid tube were observed. RESULTS: The extracts of Coptis chinensis and Magnolia officinalis with ethanol extraction and recombination could significantly inhibit the mice’s small intestine advancing rate (P<0.01) and relieve diarrhea-induced diarrhea in mice (P<0.01). The inhibitory effects of Pseudomonas aeruginosa and Staphylococcus aureus were stronger than those of Coptis horsfieldii with ethanol extraction. Conclusion: The method of extraction and recombination after the alcohol extract of Coptis chinensis has the most significant effect on the small intestine function of mice.