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前列腺素Ⅰ_2(PGI_2)和血栓素 A_2(TXA_2)对维持机体血管功能完整的内环境稳定具有重要意义。在正常生理状态下,循环血液中的 PGI_2和 TXA_2含量处于相对平衡状态。当平衡失调时,即易引起心、脑血管多种疾病。而 TXA_2是具有强烈血管收缩及促血小板凝集的活性物质,半衰期仅30秒钟,即迅速代谢为无活性的血栓素发 B_2(TXB_2)。故测定血浆 TXB_2含量,在基础医学和药理学的研究,以及对临床上脑卒中的发病机理及防治探讨具有重要意义。目前国内外文献未见到有关
PGI_2 and TXA_2 are important for maintaining the integrity of the vascular environment in vivo. Under normal physiological conditions, circulating blood PGI_2 and TXA_2 levels in a relatively balanced state. When the imbalance, that is easy to cause heart, cerebrovascular multiple diseases. TXA_2 is an active substance with strong vasoconstriction and platelet aggregation. Its half-life is only 30 seconds, which is rapidly metabolized to inactive thromboxane B 2 (TXB 2). Therefore, determination of plasma TXB_2 content, in the basic medical and pharmacological studies, as well as clinical pathogenesis and prevention and treatment of stroke is of great significance. At present, the literature has not been seen at home and abroad