1.前言神经病理性疼痛是公认的最难治疗的疼痛综合征之一,而且转归往往不尽人意。原因部分是由于神经病变产生的疼痛可能在初级医疗中未被发现,并且药物的使用未达标准。在这一领域的流行病学研究是存在疑问的,例如缺乏一致性,缺乏能真实反映病例状态和应用于人群研究的有效病例定义;再如变量的多样性研究,病例确诊的方法不同;此外,疼痛不是主诉表现,病例如何纳入或排除等。现有的一般人群患病率的评估可能变得更高,可能 1. Introduction Neuropathic pain is recognized as one of the most difficult to treat pain syndromes, and the outcome is often unsatisfactory. Part of the reason is that pain due to neuropathy may not be found in primary care and the use of medications is sub-standard. Epidemiological studies in this area are questionable, such as lack of coherence, lack of valid case definitions that truly reflect the status of the case and are used in population studies, and different approaches to variable diversity studies and case diagnosis; in addition , Pain is not the chief complaint, how to include or exclude cases. The prevalence of the current general population may be higher, possibly