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对31例生长激素(GH)缺乏症患儿进行了生长激素释放激素(GHRH)激发试验,发现14例(45.2%)在注射GHRH后15～60分钟GH峰值显著升高(>10ng/ml),峰值范围14.93～42.27ng/ml,平均24.58ng/ml,表明此类患儿系因下丘脑缺乏GHRH所致。身高在均数-3SD以下和具有典型GH缺乏症面容和体态者,GHRH缺乏组均明显少于垂体性GH缺乏组(P均<0.01),提示对一些临床表现不典型的身材矮小患儿应疑及下丘脑性GHRH缺乏。
Growth hormone releasing hormone (GHRH) challenge test was performed in 31 children with growth hormone deficiency (GHRH) and found that 14 patients (45.2%) had significantly increased peak GH (> 10ng / mL) 15-60 minutes after GHRH injection , The peak range of 14.93 ~ 42.27ng / ml, an average of 24.58ng / ml, indicating that these children due to the lack of GHRH hypothalamus. Height below the mean -3SD and with typical GH deficiency face and body posture, GHRH deficiency group were significantly less than the pituitary GH deficiency group (P all <0.01), suggesting that some of the clinical manifestations of the short stature of children should be Suspected hypothalamic GHRH deficiency.