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目的探讨妊娠期甲状腺功能减低患者的治疗方法并根据妊娠结局分析其临床效果。方法选取2008～2011年间在本院就诊的妊娠期甲状腺功能减低患者100例,本文根据患者接受药物治疗与否分为无治疗组A组50例与治疗组B组50例。评价患者的血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺激素(TSH)以及追踪其妊娠结局,剖宫产率、妊娠期高血压发生率、新生儿评分状况。结果 A、B组FT3、FT4、TSH治疗前后有着明显的变化,B组变化明显,接近正常。A组剖宫产率78%显著高于B组54%,妊娠期高血压发病率A组12%高于B组6%,新生儿Apgar评分A组高于B组。结论妊娠合并甲状腺功能减退患者适量应用左旋甲状腺素可明显降低妊娠并发症,改善妊娠结局。
Objective To investigate the treatment of patients with hypothyroidism in pregnancy and analyze the clinical effect according to the pregnancy outcome. Methods 100 cases of hypothyroidism during pregnancy in our hospital were selected from 2008 to 2011. According to whether the patients were treated with drugs or not, 50 cases in group A and 50 cases in group B were divided into two groups. Patients were evaluated for serum free triiodothyronine (FT3), free thyroxine (FT4), and hypersensitive thyroid stimulating hormone (TSH) as well as to track their pregnancy outcomes, cesarean section rates, rates of gestational hypertension, Child rating status. Results A, B group FT3, FT4, TSH before and after treatment has obvious changes, B group changed significantly close to normal. The rate of cesarean section in group A was significantly higher than that in group B (78% vs 54%). The incidence of gestational hypertension in group A was 12% higher than that in group B (6%). Neonatal Apgar score was higher in group A than in group B. Conclusions The suitable amount of L-thyroxine in patients with hypothyroidism during pregnancy can significantly reduce pregnancy complications and improve pregnancy outcomes.