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血管内皮细胞损伤在动脉粥样硬化过程中起重要作用,一氧化氮生成减少是内皮功能损伤的主要标志。C反应蛋白是动脉粥样硬化过程中的炎性标志物,可通过各种机制损伤血管内皮,参与动脉粥样硬化的病理生理过程。深入细致地研究C反应蛋白等心血管危险因素对血管内皮细胞的损伤机制将有助于动脉粥样硬化相关疾病的防治。
Vascular endothelial cell injury plays an important role in the process of atherosclerosis. The reduction of nitric oxide production is the main marker of endothelial dysfunction. C-reactive protein is an inflammatory marker of atherosclerosis, which can damage the vascular endothelium through various mechanisms and participate in the pathophysiology of atherosclerosis. In-depth study of C-reactive protein and other cardiovascular risk factors on vascular endothelial cell injury mechanism will contribute to prevention and treatment of atherosclerosis-related diseases.