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本文报告选用肝细胞微粒体混合功能氧化酶抑制剂氯霉素和诱导剂苯巴比妥对灌服咖啡酸二乙胺盐的实验小白鼠所显示凝血时间的影响,和仅服咖啡酸阳性对照组的小白鼠比较:氯霉素合用咖啡酸组的各鼠虽可明显缩短自身的凝血时间(P值<0.01),但他们的组间比较则并无显著差别(P值>0.05);而苯巴妥合用咖啡酸组鼠,不论其自身比较或组间比较,其差异均不显著(P值>0.05)。据此结果推测咖啡酸的止血药效可能和肝内生物转化的关系不大,不是代谢物,而主要是原形物的作用。而其代谢物是否和缓慢的升白等作用有关,尚有待于进一步实验证明之。
This article reports the use of hepatocyte microsomal mixed-function oxidase inhibitor chloramphenicol and inducer phenobarbital perfusion of caffeic acid diethylamine salt mice showed clotting time, and only serving caffeic acid positive control Compared with the control group, each rat in chloramphenicol and caffeic acid group could shorten its own clotting time (P <0.01), but there was no significant difference between the two groups (P> 0.05); while Phenobarb in caffeic acid group rats, regardless of their own comparison or comparison between groups, the difference was not significant (P value> 0.05). According to the results speculated that caffeic acid hemostatic efficacy may not be related to intrahepatic biotransformation, not metabolites, but mainly the role of protoplasm. And its metabolites and whether the slow rise of the role of white, yet to be further experimental proof.