论文部分内容阅读
目的探讨经肝动脉化疗栓塞术(TACE)联合部分脾动脉栓塞术(PSE)对肝癌患者免疫功能的影响及意义。方法将20例肝癌患者分为2组,即单纯TACE组(10例)和TACE联合PSE组(10例),分别于术前和术后1个月两个时间点采集外周血,采用流式细胞仪检测外周血中CD4、CD8及CD4/CD8。结果两组患者术前外周血CD4、CD8及CD4/CD8水平无差异性(P>0.05)。术后1个月TACE联合PSE组CD4(39.99±5.01)%、CD4/CD8(1.90±0.40),高于单纯TACE组CD4(30.32±5.05)%、CD4/CD8(1.08±0.21),P<0.01。而TACE联合PSE组CD8(21.73±4.68)%低于单纯TACE组(28.14±3.62)%(P<0.05)。结论 TACE术对肝癌患者免疫功能无明显影响,TACE联合PSE较单纯TACE能更好地改善机体抗肿瘤免疫功能,促进肝癌患者免疫功能平衡的恢复,也为肝癌综合介入治疗提供新思路。
Objective To investigate the effect and clinical significance of transcatheter arterial chemoembolization (TACE) and partial splenic arterial embolization (PSE) on immune function in patients with liver cancer. Methods Twenty patients with hepatocellular carcinoma (HCC) were divided into two groups: simple TACE group (n = 10) and TACE plus PSE group (n = 10). Peripheral blood was collected preoperatively and at 1 month after operation. Cytometry in peripheral blood CD4, CD8 and CD4 / CD8. Results There was no difference in the levels of CD4, CD8 and CD4 / CD8 between the two groups before operation (P> 0.05). The CD4 (superscript +) CD8 (1.90 ± 0.40) and CD4 (superscript CD8) (1.08 ± 0.21) and CD4 (superscript + 0.01. However, CD8 (21.73 ± 4.68)% in TACE combined PSE group was lower than that in pure TACE group (28.14 ± 3.62)% (P <0.05). Conclusion TACE has no significant effect on immune function in patients with liver cancer. TACE combined with PSE can better improve the anti-tumor immune function and promote the recovery of immune function in patients with liver cancer. It also provides new ideas for the comprehensive interventional treatment of liver cancer.