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人们已知胰岛素依赖性糖尿病(IDDM)与HLAⅡ类抗原DR3和DR4相关,在DR3/DR4杂合个体中产生IDDM的危险性明显增高。自发现HLA-DQ多态性以来,在IDDM研究中应用了RFLP分析,并发现一些与特定HLA-DR等位基因连锁不平衡
It is known that insulin-dependent diabetes mellitus (IDDM) is associated with the HLA class II antigens DR3 and DR4 and that the risk of IDDM in DR3 / DR4 heterozygous individuals is significantly increased. Since the discovery of HLA-DQ polymorphisms, RFLP analysis has been used in IDDM studies and found some linkage disequilibrium with specific HLA-DR alleles