自1992年STAT家族被发现以来,关于STAT家族的研究越来越多。STAT的正常表达对维持机体的许多正常功能起着关键作用,如胚胎的发育、器官形成、免疫功能的完善、细胞的生长分化等均需要STAT蛋白家族的参与,而其异常活化亦在多种疾病中被发现,如恶性肿瘤、自身免疫性疾病、病毒感染性疾病等,因此人们越来越关注STAT在这些疾病中发挥什么样的作用,从而将其作为疾病靶向性治疗的目标进行研究。 Since the STAT family was discovered in 1992, more and more studies have been conducted on the STAT family. The normal expression of STAT plays a key role in maintaining many normal functions of the body, such as the development of embryos, organ formation, the improvement of immune function, the growth and differentiation of cells need STAT protein family participation, and its abnormal activation is also a variety of Diseases have been identified, such as malignancies, autoimmune diseases, viral infections, etc. Therefore, there is growing interest in the role of STAT in these diseases and as a target for disease-targeted therapies .