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自从1926年Schülemann等合成了扑瘧喹啉(Plasmoquine)以后,30多年来,化学家們先后合成了不少有特效的抗瘧药物。近年来,在新抗瘧药的合成方面又有了进一步的发展。1963年黄兰孙等对抗瘧药近年来的化学研究作了較全面的綜述,概括了抗瘧药化学研究的新成就,并結合我国具体情况,提出了新抗瘧药合成研究的途径。由于对抗瘧药进行了深入的研究,在治疗应用方面也有了进一步的发展。抗瘧药的种类很多,过去多极据药物的化学結构分类,1962年Bruce-Chwatt根据各种药物对瘧原虫生活史中各个发育阶段的作用,将現有的抗瘧
Since the synthesis of Plasmoquine by Schülemann et al. In 1926, chemists synthesized more than 30 effective antimalarial drugs for over 30 years. In recent years, there has been further development in the synthesis of new antimalarial drugs. In 1963, Huang Lan-sun and other anti-malarial drugs in recent years made a more comprehensive review of the chemical, summarizes the new achievements of anti-malarial chemical research, combined with our specific circumstances, put forward a new route of synthetic antimalarial drug research. Because of the anti-malaria drugs conducted in-depth study, in the treatment of applications has also been further developed. There are many types of anti-malarial drugs used in the past, according to the classification of the chemical structure of the drugs. In 1962, Bruce-Chwatt, based on the effect of various drugs on various developmental stages in the life cycle of Plasmodium,