DNA甲基化是表观遗传学研究内容之一,DNA甲基化在精子发生过程对基因的表达发挥着重要的调控作用,因此了解精子发生过程中DNA甲基化的变化对精子发生障碍研究有着至关重要的价值。本文对近年来精子的DNA甲基化信息进行综述,并对辅助生殖技术所带来的遗传风险作简要探讨。 DNA methylation is one of the epigenetics research contents. DNA methylation play an important regulatory role in gene expression during spermatogenesis. Therefore, it is necessary to understand the change of DNA methylation in spermatogenesis and its influence on spermatogenesis Has a vital value. In this paper, we reviewed the DNA methylation information of sperm in recent years and briefly discussed the genetic risk of assisted reproductive technology.