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目的:初步评价化疗缓释粒子植入治疗进展期消化道肿瘤的临床疗效及不良反应。方法:选择14例隆起型病变的消化道肿瘤患者(其中胃癌12例,食管癌2例),在电子内镜直视下将5-FU缓释粒子植入到肿瘤部位,每个植入点植入5～6粒缓释粒子(氟安约10mg),并比较患者症状缓解情况及治疗前后肿瘤大小。结果:全部病例均顺利完成治疗,14例患者中12例在1～2个月后复查胃镜,病灶部分缓解及稳定,再次给予植入治疗,1例因不能耐受内镜检查而未复查,1例在做治疗之前已并发全身广泛转移,病情恶化死亡。结论:内镜下植入化疗缓释粒子治疗上消化道进展期肿瘤患者是一种新型的治疗手段,有利于肿瘤局部控制率,不失为一种毒副作用小,耐受性好的姑息治疗方法。
Objective: To evaluate the clinical efficacy and adverse reactions of chemotherapeutic delayed-release particles implantation in advanced gastrointestinal tumors. Methods: 14 cases of patients with digestive tract tumors with bulging lesions (12 cases of gastric cancer and 2 cases of esophageal cancer) were selected. 5-FU sustained-release particles were implanted into the tumor site under direct electronic endoscopy. Each implantation site Implantation of 5-6 sustained release particles (fluorine Ann about 10mg), and to compare the patient’s symptoms and treatment of tumor size before and after treatment. Results: All cases were successfully treated. In 12 of 14 patients, gastroscopy was performed after 1-2 months. The lesions were partly relieved and stabilized. The patients were re-treated with implantation. One case was not reexamined because of endoscopy failure, One patient had complicated systemic metastasis before treatment. The patient’s condition deteriorated and died. Conclusion: Endoscopic implantation of chemotherapeutic sustained-release particles in the treatment of patients with advanced upper gastrointestinal tract cancer is a new treatment method that is conducive to the local control rate of tumor, after all, it is a palliative treatment with small toxic and side effects and good tolerability.