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人体抗凝血酶Ⅱ(AT-Ⅱ)是一种活化凝血因子的强抑制剂。在弥漫性血管内凝血(DIC)、肝硬化、肾病综合征及少数遗传缺陷病时均可引起AT-Ⅱ缺乏。作者对3例DIC和严重出血倾向的病人,滴入经体外小剂量肝素激活过的人体AT-Ⅱ,随后输入浓缩凝血因子和血小板悬液,控制病人的DIC,出血倾向停止。例1男性,54岁。因肝硬化食道静脉曲张及反复胃肠道出血入院。观察期间又出血,凝血情况恶化,血培养一度绿脓杆菌生长,以浓缩AT-Ⅱ1650u滴入使AT-Ⅱ活性从37%增加到64%,然后在20分钟内给予凝血酶原复合物(PPSB),使Ⅰ及X因子活性上
Human antithrombin II (AT-II) is a potent inhibitor of activated clotting factors. In diffuse intravascular coagulation (DIC), cirrhosis, nephrotic syndrome and a small number of genetic defects can cause AT-Ⅱ deficiency. The authors of three cases of DIC and severe bleeding tendency in patients with small doses of heparin activated human in vitro AT-Ⅱ, followed by the importation of concentrated coagulation factor and platelet suspension, control of the patient’s DIC, bleeding tendency to stop. Example 1 male, 54 years old. Esophageal varices due to cirrhosis and recurrent gastrointestinal bleeding admitted to hospital. Bleeding was observed during the observation period, and the coagulation condition was deteriorated. Once Pseudomonas aeruginosa grew in blood culture, AT-II activity was increased from 37% to 64% by concentrated AT-II 1650u infusion, and then the prothrombin complex (PPSB ), I and X factor activity