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Background Self and mutual-aiding occlusive dressing is a novel method to treat with the wounds in special circumstances.This study aims to prepare a new antimicrobial adhesive for the dressing and evaluate the application effects of the adhesive.Methods The main component of the new antimicrobial adhesive was 5％ triclosan / cyanoacrylate (CA) antimicrobial adhesive.The adhesive was modified with carboxylic multi-walled carbon nanotubes (MWCNTs-COOH),multi-walled carbon nanotubes (MWCNTs),hydrophobic nano-silica,nitrile rubber,epoxy resin and polymethyl methacrylate (PMMA) respectively.The bond strength,toughness and viscosity of the modified adhesive in different concentrations were examined to select the optimal modifying material and the best ratio to prepare the new antimicrobial adhesive according to the results.After that,the antimicrobial property of the new antimicrobial adhesive was tested by filter paper method.At last,we disposed the injury models in rats using the new antimicrobial adhesive to examine the application effects.Results In individual tests,the bond strength modification performance of 0.064％ MWCNTS-COOH is the best,the bond strength is (14.71±1.48) Mpa.8％ nano-silica shows the best toughness modification performance,the Tg is (1.10±0.24)℃.The viscosity modification performance of 8％ nano-silica is the best,the viscosity is (15 536.68±28.4) cP.However,consolidating three test results,6％ nano-silica / antimicrobial adhesive has the balanced bond strength,toughness and viscosity.Its bond strength is (14.03±1.92) Mpa,the Tg is (3.60±0.68)℃,and the viscosity is (5 278.87±31.68) cP.The inhibition zone diameter of 6％ nano-silica / antimicrobial adhesive and antimicrobial adhesive group in Day 5 is (28.61±0.91) mm versus (28.24±2.69) mm (P ＞0.05).In animal studies,both in blood routine test and pathological section,6％ nano-silica / antimicrobial adhesive group shows lower white blood cells count than gauze bandage group (P ＜0.05).Conclusions 6％ nano-silica has the optimal effect of bond strength modification,toughness modification and viscosity modification,and the antimicrobial adhesive modified with it has a good antimicrobial property (resistant staphylococcus aureus).