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本文报道用高效液相色谱法对头孢哌酮国内几个厂家的产品与美国Ｐｆｉｚｅｒ厂的同种药先锋必（Ｃｅｆｏｂｉｄ）的含量进行了比较。国产品含量明显低于进口产品，二者具有显著性差异（ｐ＜０．０５）。同时，通过采取微量耳血测定其血药浓度，对８例住院病人又进行了国内外产品药物动力学的自身对照研究。结果表明：国产品与进口产品相比，峰浓度明显降低（ｐ＜０．０５），药时曲线下面积（ＡＵＣ）明显减少（ｐ＜０．０５），其余药动学参数无明显差异（ｐ＞０．０５）．本研究为临床合理应用该药提供参考数据。
This article reports the use of high performance liquid chromatography for cefoperazone domestic manufacturers of several products and the United States Pfizer factory same drug Pioneer must (Cefobid) content were compared. The content of domestic products was significantly lower than that of imported products, with significant difference (p <0.05). At the same time, by taking a small amount of ear blood test of blood concentration, 8 cases of inpatients and their products at home and abroad pharmacokinetic self-control study. The results showed that the peak concentration was significantly lower (p <0.05), the area under the curve (AUC) was significantly reduced (p <0.05), and the other pharmacokinetic parameters were not significantly different between domestic products and imported products p> 0.05). This study provides a reference data for clinical rational use of the drug.