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目的:观察生活方式干预对空腹血糖调节受损(IFG)患者胰岛β细胞功能的影响。方法:选取60例空腹血糖受损(IFG)者,将其随机分为干预组与对照组各30例,干预组给予生活方式干预,包括健康教育、饮食干预与运动干预,对照组不做任何干预。采用HOMA-IR评价胰岛素抵抗,HOMA-β及ΔI30/ΔG30分别评价基础状态下及糖负荷后的早时相胰岛β细胞功能。比较观察1年以后患者体重指数、空腹血糖、空腹胰岛素和胰岛β细胞功能的变化,从而观察生活方式干预对空腹血糖调节受损患者β细胞功能的影响。结果:干预组干预1年后BMI、FPG、FINS、HOMA-IR、HOMA-β及△I30/△G30较干预前均有显著性差异(P<0.05),与对照组相比,各指标也存在显著性差异,而对照组虽然各指标均增加,但无显著性差异(P>0.05)。结论:对空腹血糖调节受损(IFG)患者进行生活方式干预,明显改善胰岛β细胞功能及胰岛素抵抗,使第一时相胰岛素分泌缺陷得到恢复,从而预防2型糖尿病的发生,降低转化为糖尿病的风险。
Objective: To observe the effects of lifestyle intervention on pancreatic β-cell function in patients with impaired fasting glucose regulation (IFG). Methods: Sixty IFG patients were randomly divided into intervention group and control group, 30 cases each. The intervention group was given lifestyle intervention, including health education, dietary intervention and exercise intervention. The control group did not do any Intervention. HOMA-IR was used to assess insulin resistance, and HOMA-β and ΔI30 / ΔG30 were used to evaluate the early-phase islet β-cell function after basal and glucose loading. The changes of body mass index, fasting blood glucose, fasting insulin and pancreatic β-cell function were observed after 1 year to observe the effect of lifestyle intervention on β-cell function in patients with impaired fasting glucose regulation. Results: Compared with the control group, BMI, FPG, FINS, HOMA-IR, HOMA-β and △ I30 / △ G30 in the intervention group were significantly different from those before the intervention (P <0.05) There were significant differences, while the control group although each index increased, but no significant difference (P> 0.05). CONCLUSION: Life style intervention in patients with impaired fasting glucose regulation (IFG) significantly improves pancreatic β-cell function and insulin resistance, restores the first-phase insulin secretion defects and thus prevents the occurrence of type 2 diabetes and reduces the conversion to diabetes risks of.