目的:探讨抗结核药物所致肝脏毒性与脂质过氧化的关系.方法:以经抗结核药物治疗后发生肝脏损害的肺结核病人为研究对象,以血清过氧化脂质(LPO)、超氧化物歧化酶(SOD)和还原型谷胱甘肽(GSH)为指标,观察肝损害脂质过氧化及抗氧化的关系.结果:有肝脏损害病人的血清脂质过氧化水平明显高于对照组,而血清超氧化物歧化酶和还原型谷胱甘肽显著低于对照组.结论:由抗结核药物所引起的肝脏损害与体内的脂质过氧化有关,且会消耗体内的抗氧化物质. Objective: To investigate the relationship between liver toxicity and lipid peroxidation induced by anti-tuberculosis drugs.Methods: The pulmonary tuberculosis patients with liver damage after antituberculotics treatment were taken as the research object, and serum lipid peroxides (LPO), superoxide (SOD) and reduced glutathione (GSH) were measured to observe the relationship between lipid peroxidation and anti-oxidation in liver damage.Results: Serum lipid peroxidation in patients with liver damage was significantly higher than that in the control group, While serum superoxide dismutase and reduced glutathione were significantly lower than those in the control group.Conclusion: The liver damage caused by anti-tuberculosis drugs is related to the lipid peroxidation in the body and may consume the antioxidants in the body.