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口服避孕药是当代应用较广泛的避孕措施之一,据估计,全世界有5千余万妇女用药。在长期用药过程中可能同时服用其它药物,如果在口服避孕药期间同服肝微粒体代谢酶(旧称肝药酶)诱导剂即可导致避孕失败,兹将临床遇到的2例报告如下。[例1] 张某,女,31岁,孕2产1,流产1次。因下腹部绞痛伴呕吐1小时入院。患者患肺结核4年,以前均用第一线抗痨药物治疗,近4个月加用利福平450毫克/日,清
Oral contraceptives are one of the more widely used forms of contraception in the contemporary era and it is estimated that more than 50 million women in the world consume it. In the course of long-term medication may take other drugs at the same time, if oral administration of contraceptives with liver microsomal metabolic enzymes (formerly liver enzyme enzyme) inducing agents can lead to contraceptive failure, the clinical encounter in 2 cases are reported as follows. [Example 1] Zhang, female, 31 years old, 2 pregnant 1, 1 abortion. Due to abdominal cramps with vomiting 1 hour admitted. Patients suffering from pulmonary tuberculosis 4 years ago, were used first-line anti-tuberculosis drugs, nearly 4 months plus rifampicin 450 mg / day, clear