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目的探讨自然免疫状态下血清抗肺炎链球菌荚膜多糖特异性抗体值,为老年人是否需常规使用PPV23免疫提供参考。方法健康人85例(健康组),分为青年、中年、老年组;老年COPD患者18例(COPD组),ELISA检测血清特异性抗体。结果健康组:IgA老年组同中、青年组差异无统计学意义;IgM青年组高于其他两组(P<0.05);总IgG差异无统计学意义,IgG4老年及中年组高于青年组(P<0.05)。IgM浓度与年龄负相关(r=-0.274,P<0.05),IgG4与年龄正相关(r=0.342,P<0.05)。COPD组和健康老年人组差异无统计学意义。结论未发现健康及COPD老年人血清抗肺炎链球菌保护性抗体整体水平低下,不支持该人群常规使用PPV23。
Objective To investigate the value of serum anti-S. pneumoniae capsular polysaccharide antibody against natural immune status in order to provide a reference for the elderly to use PPV23 routinely. Methods Totally 85 healthy subjects (healthy group) were divided into young, middle-aged and elderly groups. 18 elderly COPD patients (COPD group) and serum specific antibodies were detected by ELISA. Results There was no significant difference between the healthy group and the young and middle-aged IgA group; the IgM group was higher than the other two groups (P <0.05); there was no significant difference between the two groups (P <0.05). The concentration of IgM was negatively correlated with age (r = -0.274, P <0.05). IgG4 was positively correlated with age (r = 0.342, P <0.05). There was no significant difference between COPD group and healthy elderly group. Conclusions The overall level of serum anti-pneumococcal protective antibodies in healthy and COPD-free elderly people was not found to be low, and routine use of PPV23 was not supported in this population.