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对30例巨脾型和19例已切脾的晚期血吸虫病(晚血)患者及 41例对照人群进行外周血 NK细胞活性、红细胞C_(3b)受体花环率、中性粒细胞吞噬功能和淋巴细胞转化试验测定以检测晚血患者的细胞免疫功能变化及脾切除对其影响。结果显示,晚血巨脾型患者上述免疫功能均明显低于对照人群,切脾患者 NK细胞活性、红细胞C_(3b)受体花环率明显高于巨脾组。晚血患者中性粒细胞吞噬指数及淋巴细胞转化功能已呈抑制,但切脾组与巨脾组之间无明显差异。表明脾切除不仅能降低门脉高压,同时也有可能改善患者的细胞免疫调节功能,增加患者抵抗力。
Thirty patients with splenomegaly and 19 patients with advanced schistosomiasis who had splenectomy and 41 controls were enrolled in this study. The changes of NK cell activity, erythrocyte C_ (3b) rosette rate, neutrophil phagocytosis, Lymphocyte transformation test to detect changes in patients with late blood cell immune function and splenectomy on the impact. The results showed that the immune function of the late-splenomegaly splenic patients were significantly lower than that of the control group. The NK cell activity and Rb of the erythrocyte Cb receptor were significantly higher in splenectomy patients than in splenomegaly. The neutrophil phagocytic index and lymphocyte transformation function in patients with late blood have been inhibited, but there is no significant difference between the splenectomy group and the splenomegaly group. That splenectomy can not only reduce portal hypertension, but also may improve the patient’s cellular immune regulatory function and increase patient resistance.