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[目的]提高对Gilbert综合征临床诊断水平。[方法]回顾性分析我院收治、确诊的19例Gilbert综合征患者资料。[结果]19例高胆红素血症患者均以间接胆红素升高为主(24.7~157.4μmol/L),直接胆红素轻度升高(7.9~23.5μmol/L),少数患者,直接胆红素正常。患者绝大多数是青年男性。黄疸出现的年龄,多数为青少年。黄疸是主要临床表现。所有病例,经过肝脏穿刺病理检查,肝脏组织结构基本正常,确诊Gilbert综合征。所有病例的血常规、肝脏的酶学、肝炎的病原学、自身免疫性肝炎的抗体、腹部B超等检查,全部正常。[结论]Gilbert综合征是临床少见的先天性黄疸。临床表现为慢性、非溶血性、间接胆红素增高为主的高胆红素血症,预后良好。
[Objective] To improve the clinical diagnosis of Gilbert’s syndrome. [Methods] The data of 19 patients with Gilbert syndrome admitted to our hospital were retrospectively analyzed. [Results] The indirect hyperbilirubinemia was mainly elevated in indirect hyperbilirubinemia patients (24.7 ~ 157.4μmol / L) and mildly elevated direct bilirubin (7.9 ~ 23.5μmol / L) in 19 patients. A few patients Direct bilirubin normal. The vast majority of patients are young men. The age at which jaundice appears is mostly for adolescents. Jaundice is the main clinical manifestation. All cases, after liver biopsy, the liver tissue structure was normal, diagnosed Gilbert syndrome. All cases of blood, liver enzymes, hepatitis etiology, autoimmune hepatitis antibodies, abdominal B ultrasound examination, all normal. [Conclusion] Gilbert syndrome is a rare clinical congenital jaundice. Clinical manifestations of chronic, non-hemolytic, indirect hyperbilirubinemia mainly elevated bilirubin, prognosis is good.