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目的分析研究大剂量环磷酰胺冲击治疗狼疮性肾炎的护理策略。方法选取2011年4月~2015年4月在我院进行大剂量环磷酰胺冲击治疗狼疮性肾炎的患者42例,对42例患者采取针对性的护理干预,对其干预效果给予分析研究。结果 42例患者当中16例在冲击治疗以后48 h内发生恶心、食欲不振以及呕吐等相关胃肠道反应,经过对症处理以后得到好转。另外,继发性肺部感染有8例,口腔霉菌感染有4例,经过抗感染治疗以后得到改善。发生出血性膀胱炎有2例,经过止血和膀胱进行冲洗等相关处理以后好转。结论对大剂量环磷酰胺冲击治疗狼疮性肾炎患者采取针对性的护理干预,可以使治疗效果提高,并且并发症较少,具有安全性。
Objective To analyze the nursing strategy of high dose cyclophosphamide in the treatment of lupus nephritis. Methods Forty-two patients with lupus nephritis treated with high-dose cyclophosphamide in our hospital from April 2011 to April 2015 were selected. Forty-two patients were treated with specific nursing intervention and the intervention effect was analyzed. Results 16 of 42 patients developed nausea, loss of appetite and vomiting and other related gastrointestinal reactions within 48 h after the shock therapy. After symptomatic treatment, the symptoms were improved. In addition, 8 cases of secondary lung infections, oral mold infections in 4 cases, after anti-infective treatment was improved. Hemorrhagic cystitis occurred in 2 cases, after hemostasis and bladder flushing and other related improvements later. Conclusion High-dose cyclophosphamide shock treatment of lupus nephritis patients take targeted nursing intervention can make the treatment effect, and less complications, with safety.