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目的探讨太原市PM2.5对哮喘患者机体炎症因子的季节影响。方法以太原市不同社区哮喘患者29例为研究对象,在2013年分春、夏、秋三季对其生活环境PM2.5监测1周,并采集血样检测炎症因子。统计分析采用方差分析及非参数检验。结果哮喘患者春季室外PM2.5[(185.89±37.30)μg/m3]、室内PM2.5[(170.30±23.84)μg/m3]和个体PM2.5暴露值[(186.91±35.66)μg/m3]均高于相应秋季暴露值(148.48±26.40,77.50±9.43,82.11±8.46)μg/m3(P<0.05);哮喘患者血浆春季COX-2浓度19.60(6.36)μg/L高于秋季浓度10.73(3.96)μg/L,春季Eotaxin浓度9.43(2.78)ng/L高于秋季浓度5.42(1.57)ng/L,春季IL-10浓度3.24(1.55)ng/L低于秋季5.45(1.37)ng/L(P<0.012 5);室外PM2.5浓度、室内PM2.5暴露浓度以及个体PM2.5浓度与COX-2、Eotaxin呈正相关(P<0.05),与IL-10呈负相关(P<0.05)。结论 PM2.5可能通过影响哮喘患者机体相应炎症因子的表达加重哮喘疾病。
Objective To investigate the seasonal effects of PM2.5 in Taiyuan on the inflammatory cytokines in asthmatic patients. Methods Twenty-nine patients with asthma in different communities in Taiyuan City were selected as experimental subjects. PM2.5 was monitored for one week in spring, summer and autumn in 2013, and blood samples were collected for the detection of inflammatory cytokines. Statistical analysis using analysis of variance and non-parametric test. Results PM2.5 [(185.89 ± 37.30) μg / m3], PM2.5 [(170.30 ± 23.84) μg / m3] and PM2.5 exposure [(186.91 ± 35.66) μg / m3] (148.48 ± 26.40,77.50 ± 9.43,82.11 ± 8.46) μg / m3 (P <0.05), respectively; the plasma COX-2 concentration in spring was 19.60 (6.36) μg / L higher than that in autumn with a concentration of 10.73 3.14 μg / L, and the concentration of Eotaxin in spring was 9.43 (2.78) ng / L higher than that of autumn 5.42 (1.57) ng / L. (P <0.012 5). PM2.5 concentration, indoor PM2.5 concentration and individual PM2.5 concentration were positively correlated with COX-2 and Eotaxin (P <0.05), but negatively correlated with IL-10 ). Conclusion PM2.5 may aggravate asthma diseases by affecting the expression of the corresponding inflammatory cytokines in asthmatic patients.