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目的 :探讨早期诊断肾脏损伤的方法 ,联合尿NAG及尿mALB两项指标对于肾病的早期诊断具有一定的价值。方法 :采用速率法测定尿NAG、血尿素 (BU) ,Jaffe速率法测尿肌酐 ,免疫速率散射比浊法测尿mALB。结果 :正常对照组尿NAG为 (9.37± 4 .2 1)IU/ gCr ,尿mALB为 (12±10 ) μg/ml,血尿素为 (4.71± 1.5 0 )mmol/L ,疾病组尿NAG及mALB较正常对照组显著增高 (P <0 .0 0 1) ;糖尿病组血尿素较正常对照组显著增高 (P <0 .0 0 1) ,高血压组血尿素较正常对照组增高(P <0 .0 5 ) ,红斑狼疮与尿路感染组血尿素较正常对照组无显著性差异。尿NAG在糖尿病、高血压、系统性红斑狼疮及尿路感染中阳性率分别达 5 6 .2 5 %、5 2 .17%、4 0 %和 4 0 % ,分别较血BU的阳性检出率高出 34.37%、34.78%、2 0 %和 2 6 .6 7% ;而尿mALB在糖尿病、高血压、系统性红斑狼疮及尿路感染中阳性率分别为 5 0 %、4 7.82 %、5 0 %和 4 6 .6 7% ,分别较血BU的阳性检出率高出2 8.12 %、30 .4 3%、30 %和 33.34%。结论 :尿NAG及mALB是诊断肾脏早期损伤灵敏、可靠的实验室指标。
Objective: To explore the method of early diagnosis of renal injury, urinary NAG and urinary mALB two indicators for the early diagnosis of kidney disease has a certain value. Methods: Urinary NAG, BU, Jaffe rate method were used to measure urinary creatinine. Urinary mALB was measured by immunostaining nephelometry. Results: The urinary NAG in the control group was (9.37 ± 4.21) IU / gCr, the urinary mALB was (12 ± 10) μg / ml, the blood urea level was (4.71 ± 1.5) mmol / L, (P <0.01). The level of blood urea nitrogen in diabetic group was significantly higher than that in normal control group (P <0.01), and the level of blood urea nitrogen in hypertension group was higher than that in normal control group (P < 0 .0 5), lupus erythematosus and urinary tract infection blood urea than the normal control group no significant difference. The positive rates of urinary NAG in diabetes, hypertension, systemic lupus erythematosus and urinary tract infection were 56.25%, 52.27%, 40.0% and 40.0%, respectively, which were higher than that of blood BU The rates of urinary mALB in diabetes, hypertension, systemic lupus erythematosus and urinary tract infection were 50%, 4 7.82%, respectively. The positive rate of urinary mALB was 34.37%, 34.78%, 20.0% and 26.67% 50% and 46.67%, respectively, higher than the positive detection rate of blood BU 2.12%, 30.34%, 30% and 33.34%. Conclusion: Urinary NAG and mALB are sensitive and reliable laboratory indexes for diagnosis of early renal injury.