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用洛赛克、泰胃美及钙通道阻滞剂治疗127例经胃镜证实的活动性消化性溃疡。洛赛克组(简称洛组)35例,每晨服20mg,疗程4～6周。泰胃美组(简称泰组)32例,每晚服800mg,疗程为8周。钙通道阻滞剂组(简称CCBA组)60例,服硝苯啶10mg,tid或尼莫地平20mg tid,CCBA组分为CCBA-Ⅰ组(疗程为8周)和CCBA-Ⅱ组(长期用药)。洛组、泰组、CCBA组的溃疡痊率分别为97.1％,87.5％,83.3％。洛组、泰组、CCBA-Ⅰ组的6个月复发率分别为23.5％,32.1％,34.6％,12个月复发率分别为35.3％,71.4％,73.1％。长期服药的CCBA-Ⅱ组6个月内无复发,12个月内仅1例复发。上述结果提示洛赛克是治疗消化性溃疡非常有效的药物,而钙通道阻滞剂长期服用能有效地预防溃疡复发。
127 cases of active peptic ulcer confirmed by gastroscope were treated with Losec, TTS, and calcium channel blockers. Losec group (Los group) 35 cases, each morning service 20mg, treatment of 4 to 6 weeks. Thai stomach beauty group (referred to as Thai group) 32 cases, 800 mg per night, treatment for 8 weeks. Sixty patients in the CCB group (n = 10) received nifedipine 10 mg, tid or nimodipine 20 mg tid respectively. The CCBA group consisted of CCBA-Ⅰ (for 8 weeks) and CCBA-Ⅱ ). The recovery rates of ulcer in Los group, Tai group and CCBA group were 97.1%, 87.5% and 83.3% respectively. The 6-month recurrence rates in Luohu, Tai and CCBA-Ⅰ groups were 23.5%, 32.1% and 34.6% respectively, and the recurrence rates at 12 months were 35.3%, 71.4% and 73.1% respectively. Long-term medication CCBA-Ⅱ group no recurrence within 6 months, only 1 case of recurrence within 12 months. These results suggest that Losec is very effective in the treatment of peptic ulcer drugs, and long-term use of calcium channel blockers can effectively prevent the recurrence of ulcers.