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熊去氧胆酸(Ursodeoxycholic acid简称UDCA)是有效的利胆剂,能较好地溶解胆固醇胆结石,而且剂量小,疗程短,副作用小,还有解痉和抗惊厥作用。我们研究了一条收率较高,工艺稳定的UDCA半合成路线,成品有明显利胆作用,对血清胆固醇和甘油三酯的降低作用十分显著,其它理化性质也与文献报导完全一致。熊去氧胆酸的定量方法主要有中和法,比色法和气相层析法。前两法缺少测定专一性,后一方法需制备衍生物,操作不便。因此我们建立了薄层定量法,可供半合成品熊去氧胆酸及其制剂的含量测定。
Ursodeoxycholic acid (abbreviated as UDCA) is an effective choleretic agent that can dissolve cholesterol gallstones well, and has a small dose, short course of treatment, small side effects, antispasmodic and anticonvulsant effects. We have studied a semi-synthetic route of UDCA with high yield and stable process. The finished product has obvious beneficial effect on gallbladder. The reduction of serum cholesterol and triglyceride is very significant. Other physicochemical properties are also consistent with the literature reports. The quantification methods for ursodeoxycholic acid include neutralization, colorimetry and gas chromatography. The first two methods lack the specificity of determination, and the latter method requires the preparation of derivatives, which is inconvenient to operate. Therefore, we established a thin layer quantification method for the determination of semi-synthetic ursodeoxycholic acid and its preparations.