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目的:探讨COX-2及c-met蛋白在疣状胃炎与胃癌中的表达情况及其临床意义。方法:收集2011年3月至2013年12月在南方医科大学附属小榄医院经内镜与病理学检查诊断为疣状胃炎(80例)、慢性浅表性胃炎(50例)、胃癌(50例)的患者作为研究对象。采用免疫组织化学SP法检测胃黏膜COX-2和c-met蛋白表达水平。结果:COX-2阳性着色分布于细胞质内或核膜上,呈棕黄(褐)色染色;c-met蛋白阳性着色分布于细胞膜,呈棕黄色。疣状胃炎组COX-2及c-met蛋白表达水平明显高于慢性浅表性胃炎组(P<0.05),而与胃癌组比较,差异无统计学意义(P>0.05)。结论:COX-2及c-met可能参与疣状胃炎的癌变过程,应积极治疗、密切随访。
Objective: To investigate the expression of COX-2 and c-met protein in verrucous gastritis and gastric cancer and its clinical significance. Methods: From March 2011 to December 2013, 80 cases of verrucous gastritis (80 cases), 50 cases of chronic superficial gastritis (50 cases) and 50 cases of gastric cancer (50 cases) were diagnosed by endoscopy and pathology in the Affiliated Xiaolan Hospital of Southern Medical University Patients) as the research object. Immunohistochemical SP method was used to detect the expression of COX-2 and c-met protein in gastric mucosa. Results: COX-2 positive staining distributed in cytoplasm or nuclear membrane, brown brown brown staining; c-met protein positive staining distributed in the cell membrane, brown yellow. The expression levels of COX-2 and c-met in verrucous gastritis group were significantly higher than those in chronic superficial gastritis group (P <0.05), but not statistically different from those in gastric cancer group (P> 0.05). Conclusion: COX-2 and c-met may be involved in the carcinogenesis of verrucous gastritis. They should be actively treated and followed up closely.