目的:建立昆明小鼠子宫内膜异位症模型,选取胞饮突电镜观察的最佳时间位点。方法:以同系小鼠作为供体,取子宫内膜采用腹腔及皮下注射法对20只小鼠建立子宫内膜异位症模型。以雄性不育小鼠以2∶1合笼,次日8∶00见阴栓者为0 h。于第80 h、84 h、85 h、85.5 h、86.5 h、87 h、88 h、91 h、95 h及未假孕的小鼠,取子宫内膜行电镜观察。结果:造模成功率为90%,镜下可见第86.5 h的胞饮突生长饱满。结论:通过建立子宫内膜异位症昆明小鼠模型,成功率较高,且简单易行。胞饮突是子宫内膜容受性的重要形态学标记,它的出现与内膜种植窗口期相一致。电镜观察:在见阴栓86.5 h后,胞饮突发育完全;在见栓后80 h、84 h、85 h和85.5 h胞饮突处于发育中;在见栓后87 h、88 h、91 h和95h胞饮突逐渐退化。 Objective: To establish a model of endometriosis in Kunming mice and select the best time point for the observation by electron microscopy. Methods: Homologous mice were used as donors. The endometrium was taken and the endometriosis model was established in 20 mice by intraperitoneal and subcutaneous injection. The male sterile mice were caged at 2: 1, and the vaginal suppository was 0 h at 8:00 the next day. At the end of the 80th, 84th, 85th, 85th, 85th, 86th, 87th, 88th, 91th, 95th hour and non-pseudopregnant mice, the endometrium was observed by electron microscope. Results: The successful rate of model making was 90%. Conclusion: Kunming mouse model of endometriosis has a high success rate and is simple and easy to operate. The pinocyst is an important morphological marker of endometrial receptivity. Its appearance coincides with the window of endometrial implantation. Electron microscope observation showed that the pinopodes developed completely after 86.5 h of the suppository. In 80 h after hindministration, 84 h, 85 h and 85.5 h were observed in the developing process. After 87 h, 88 h, 91 h and 95h pinopodes gradually degenerated.