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目的测定毛细支气管炎患儿急性发作期和恢复期血Th1细胞(T-helper-1)和Th2细胞(T-helper-2),研究Th1/Th2失衡和毛细支气管炎急性发作的关系,推断T淋巴细胞在毛细支气管炎发生发展过程中的作用。方法观察组35例毛细支气管炎患儿,分别于治疗前和治疗后应用流式细胞术测定血样本中Th1和Th2数量;对照组11例。结果观察组治疗前Th2明显升高,Th1/Th2比值明显降低,与对照组比较有统计学差异(P<0.01);观察组治疗后Th2有所下降,Th1/Th2比值有所增加,与治疗前比较有统计学差异(P<0.01),但与对照组比较差异仍有统计学意义(P<0.01)。结论Th2优势应答可能在毛细支气管炎急性发作过程中起重要作用。
Objective To determine the relationship between Th1 / Th2 imbalance and acute exacerbation of bronchiolitis in children with bronchiolitis at acute and convalescent stages. To investigate the relationship between T Role of lymphocytes in the development of bronchiolitis. Methods 35 children with bronchiolitis were observed in the observation group. The numbers of Th1 and Th2 in the blood samples were measured by flow cytometry before treatment and after treatment. The control group, 11 cases. Results The observation group had significantly increased Th2 and Th1 / Th2 ratio compared with the control group (P <0.01). Th2 decreased and the ratio of Th1 / Th2 increased in the observation group compared with the control group (P <0.01), but the difference with the control group was still statistically significant (P <0.01). Conclusions The predominant Th2 response may play an important role in the acute episode of bronchiolitis.