目的　国外学者研究发现 Endoglin基因多态性与散发性脑出血有关 ,国内尚未见报道 ,我们的研究探讨了 Endoglin基因插入 /缺失 (I/ D)多态性与中国人群脑出血发病的相关关系。方法　利用等位基因特异性聚合酶链反应技术分析了 15 0例原发性脑出血患者和 15 0例非脑血管病对照组 Endoglin基因的多态性位点频率。结果　在所研究的人群中 Endoglin基因第 7内含子的基因型全为缺失型纯合子 ,没有插入型的等位基因。结论　Endoglin基因插入 /缺失多态性与中国人群的脑出血没有相关关系。 Objective To study the association between Endoglin gene polymorphism and sporadic intracerebral hemorrhage in our country. We have not reported yet in our country. Our study explored the relationship between Endoglin gene insertion / deletion (I / D) polymorphism and the incidence of cerebral hemorrhage in Chinese population. Methods The allele-specific polymerase chain reaction (PCR) technique was used to analyze the polymorphism sites of Endoglin gene in 150 patients with primary cerebral hemorrhage and 150 non-cerebrovascular disease controls. Results The genotypes of the 7th intron of Endoglin gene in the studied population were all deletion homozygotes without insertional alleles. Conclusion There is no correlation between Endoglin gene insertion / deletion polymorphism and cerebral hemorrhage in Chinese population.