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目的 :探讨眼底血流动力学改变与慢性闭角型青光眼视功能损害的关系。方法 :利用彩色多普勒超声技术 ( CDI)对慢性闭角型青光眼 ( CPCAG)患者的不同病程阶段的眼动脉 ( OA)、视网膜中央动脉 ( CRA)、睫状后短动脉 ( PCAs)的血流参数进行检测 ,对 CPCAG患者视野指数平均缺损值 ( MD)与 OA、CRA、PCAs阻力指数 ( PI)的相关性分别进行研究。结果 :1 CPCAG患者无论是OA还是 CRA、PCAs,其收缩期峰值血流速度 ( PSV)、舒张末期血流速度 ( EDV)、平均血流速度( Vmean)均较正常人减少 ,阻力指数 ( RI)较正常人高 ( P<0 .0 1 )。 2 CPCAG患者的视野 MD值与OA、CRA和 PCA的 RI之间呈显著负相关 ( P<0 .0 1 )。 3CPCAG组随着视野损害的不断进展 ,其眼底血流速度逐渐下降 ,在尚未出现眼底及视野改变的 CPCAG患者中 ,CRA的 EDV降低 ,与正常对照组相比存在显著差异 ( P<0 .0 5)。结论 :1 CPCAG患者存在着视盘和视网膜的血液供应障碍。 2 CPCAG患者的视野损害与眼底血管末梢阻力的增加有关。 3CDI对 CPCAG的早期诊断及病程监测具有重要价值。
Objective: To investigate the relationship between fundus hemodynamic changes and visual impairment of chronic angle-closure glaucoma. Methods: The color Doppler echocardiography (CDI) was used to evaluate the changes of ocular artery (OA), central retinal artery (CRA), and posterior ciliary shortening (PCAs) in patients with chronic angle closure glaucoma (CPCAG) Flow parameters were detected in patients with CPCAG average visual field index (MD) and OA, CRA, PCA resistance index (PI) were studied. Results: 1 CPCAG patients with OA or CRA, PCAs peak systolic velocity (PSV), end-diastolic velocity (EDV), mean blood flow velocity (Vmean) were lower than normal, resistance index ) Than normal (P <0.01). 2 There was a significant negative correlation between the MD values of CPCAG and the RIs of OA, CRA and PCA (P <0.01). In the 3CPCAG group, the rate of fundus blood flow decreased gradually with the progression of visual field damage. EDCP of CRA decreased in patients with CPCAG who had not seen fundus and visual field changes, there was significant difference compared with the normal control group (P <0. 0 5). CONCLUSIONS: 1 CPCAG patients have disorders of blood supply to optic disc and retina. 2 CPCAG patients with visual field damage and increased retinal vascular resistance. 3CDI is of great value in the early diagnosis and course monitoring of CPCAG.