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目的 :寻找快速测定药物过量患者苯二氮类药物 (BZDs)血药浓度的方法。方法 :对149例急诊疑为药物过量患者 ,采用荧光偏振免疫法测定其BZDs血药浓度。结果 :104例血中测出BZDs ,且不同种类的BZDs血药浓度高低不一。结论 :以本法测定BZDs血药浓度对临床及时诊断和治疗有一定参考价值 ,但其浓度高低与患者病情的轻重并无必然联系。
OBJECTIVE: To find a rapid method for the determination of plasma concentrations of benzodiazepines (BZDs) in overdose patients. Methods: A total of 149 patients with suspected overdosage were enrolled in this study. Plasma concentrations of BZDs were measured by fluorescence polarization immunoassay. Results: BZDs were detected in 104 blood samples, and blood levels of different types of BZDs varied. Conclusion: The blood concentration of BZDs determined by this method has certain reference value for clinical diagnosis and treatment in time. However, the concentration of BZDs is not necessarily related to the severity of the disease.