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氟喹诺酮是目前广泛用于临床对付多种感染性疾病的一类安全性相对较高的抗菌药 ,其常见的不良反应 (胃肠道紊乱、中枢神经系统反应、皮肤反应和药物相互作用等 )程度轻微且具有可逆性。某些品种因上市后经大规模使用逐渐出现严重的毒副作用而撤出市场或被严格限制使用。对此应该引起人们的高度重视。本文根据MEDLINE搜索 1980年以来所有涉及氟喹诺酮安全性的二百多篇文献以及近期 9篇会议报道对这类药物 ,特别是目前临床上使用的品种的安全性进行了综述 ,以达到安全有效的合理用药之目的。
Fluoroquinolones are a class of relatively safe antimicrobial agents widely used in clinical treatment of various infectious diseases. The common adverse reactions (gastrointestinal disorders, central nervous system reactions, skin reactions and drug interactions) Slightly and reversibly. Certain varieties have been withdrawn from the market or have been severely restricted in their use due to the gradual emergence of serious side effects after their large-scale use. This should arouse people’s attention. This article reviews over 200 articles covering the safety of fluoroquinolones since 1980 and reviews of the safety of these drugs, especially currently used in clinical practice, over 200 articles from MEDLINE and in recent 9 meetings in order to achieve a safe and effective Rational use of the purpose.