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目的 :研究 2型糖尿病 (DM)患者 5种微量蛋白在糖尿病肾病早期诊断中的价值。方法 :对 1 36例 2型DM患者采用酶标免疫的方法测定尿视黄醇结合蛋白 (RBP)、清蛋白 (ALB)、免疫球蛋白G(IgG)、转铁蛋白 (TRF) ;用分光光度法测定尿N 乙酰 β 氨基葡萄糖苷酶 (NAG)。 结果 :1 36例 2型DM患者尿 5种微量蛋白的阳性率均高于尿常规蛋白的阳性率 (P <0 0 1 )。尿常规蛋白阳性的尿RBP、ALB、IgG、TRF均比尿常规蛋白阴性的阳性率高 (P <0 0 1 )。不同病程DM随着病程的延长尿 5种微量蛋白的阳性率越高。结论 :联合检测DM患者系列尿微量蛋白有助于早期预防和诊断糖尿病肾病
Objective: To study the value of five trace proteins in the early diagnosis of diabetic nephropathy in type 2 diabetes mellitus (DM). Methods: Urinary retinol binding protein (RBP), albumin (ALB), immunoglobulin G (IgG) and transferrin (TRF) were measured by enzyme-linked immunosorbent assay in 136 cases of type 2 DM patients. Spectrophotometric determination of urinary N acetylglucosaminidase (NAG). Results: The positive rates of urinary 5 kinds of microalbumin in 36 cases of type 2 DM patients were higher than that of urine routine proteins (P <0.01). Urinary routine protein positive urine RBP, ALB, IgG, TRF were higher than those of urinary protein negative (P <0.01). Different duration of diabetes DM with the extension of the duration of urine 5 kinds of trace protein, the higher the positive rate. Conclusion: The combined detection of urine microalbumin in DM patients is helpful for the early prevention and diagnosis of diabetic nephropathy