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目的 观察芬太尼透皮贴剂 (多瑞吉 )在中重度癌痛病人中的止痛疗效 ,不良反应及对生活质量的影响。方法 共有 6 2例确诊为恶性肿瘤并伴有中重度癌痛者入组 ,采用自行评分法如疼痛指数在≥ 6时。给予多瑞吉以小剂量 2 5ug/h开始或根据原使用的吗啡剂量折算出多瑞吉剂量 ,贴于前胸腹壁 ,每 3天更换贴剂 ,并酌情调整剂量。在用药前及用药后 15天及 30天分别进行生活质量的评估。结果 用药后止痛有效率为 70 .97%( 4 4/6 2 )。对慢性持续性疾病的止痛疗效优于急性疼痛。不良反应发生率低 ,多为轻度的嗜睡、恶心呕吐等 ,用药后生活质量有不同程度的改善。特别是在食欲、睡眠和精神方面有较大的改善。但仍有 15 %的患者达不到止痛的目的。结论 芬太尼透皮贴剂对于伴有中重度癌痛的多数患者止痛疗效满意 ,不良反应发生率低 ,能改善患者的生存质量 ,适于多数中重度癌痛者无创止痛无痛死亡的要求。是胃肠外阿片类镇痛的良好替代品。
Objective To observe the analgesic efficacy, adverse reactions and quality of life of fentanyl transdermal patch in the patients with moderate to severe cancer pain. Methods A total of 62 cases were diagnosed as malignant tumors with moderate to severe cancer pain. Patients were enrolled in this study. Give Doris a low dose of 25ug / h or according to the original dose of morphine converted Doric dose, affixed to the anterior abdominal wall, every 3 days replacement patch, and adjust the dose, as appropriate. Quality of life was assessed before medication and 15 days and 30 days after treatment. Results After treatment analgesic effective rate was 70.97% (4 4/6 2). Chronic persistent disease pain relief is better than acute pain. The incidence of adverse reactions is low, mostly mild drowsiness, nausea and vomiting, after treatment with varying degrees of quality of life improvement. Especially in the appetite, sleep and mental aspects have greatly improved. However, there are still 15% of the patients failing to achieve analgesia. Conclusions Fentanyl transdermal patch is effective in relieving pain in most patients with moderate to severe cancer pain and has a low incidence of adverse reactions, which can improve the quality of life of patients and is suitable for painless death of non-invasive pain in most moderate-to-severe cancer pain patients . Is a good alternative to parenteral opioid analgesics.