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目的 :探讨放疗疗程延长对鼻咽癌疗效的影响。方法 :1990年— 1995年间 ,因休假致疗程中断的鼻咽癌 176例与同期连续放疗的 182例进行对比 ,均接受常规分割放疗。有中断的 176例中 ,2 6例曾补量照射。疗程延长时间为 5天～ 15天不等。结果 :疗程延长的 176例中 ,局部失败 4 7例 ,3年生存率为 6 0 .9% ,5年生存率为 4 1.6 % ;连续的 182例中 ,局部失败 4 2例 ,3年生存率为 75 .6 % ,5年生存率为 5 4 .7%。在 <36 Gy前中断的 84例 ,局部失败 17例 ,3年生存率为 6 8.5 % ,5年生存率为 4 9.6 % ;≥ 36 Gy后中断的 92例 ,局部失败 30例 ,3年生存率为 5 4 .3% ,5年生存率为 33.6 %。补量的 2 6例 ,局部失败 6例 ,3年生存率为 72 .8% ,5年生存率为 4 9.3%。结论 :鼻咽癌因节假日休息等因素使总疗程延长时 ,其局控率和 3年、5年生存率均会下降。在剂最≥ 36 Gy后中断放疗 ,疗效影响更明显。补量组疗效明显优于不补量组。
Objective: To investigate the effect of prolonged radiotherapy on the efficacy of nasopharyngeal carcinoma. Methods: Between 1990 and 1995, 176 cases of nasopharyngeal carcinoma with interruption of treatment due to vacation were compared with 182 cases of continuous radiotherapy during the same period, and received conventional radiotherapy. Of the 176 cases with interruptions, 26 had radiation exposure. Duration of treatment is 5 days to 15 days. Results: Of the 176 cases with prolonged course of treatment, 47 cases failed locally, the 3-year survival rate was 60.9% and the 5-year survival rate was 41.6%. Among 182 consecutive cases, 42 cases failed locally and 3 years survival rate The rate was 75.6% and the 5-year survival rate was 54.7%. Eighty-four cases were discontinued before <36 Gy, with 17 cases of partial failure, 3-year survival rate of 8.55%, and 5-year survival rate of 9.6%. 92 patients discontinued after 36 Gy, 30 cases of local failure and 3 years of survival The rate was 54.3% and the 5-year survival rate was 33.6%. There were 26 cases of partial replacement, 6 cases of partial failure, 3-year survival was 72.8% and 5-year survival was 4 9.3%. Conclusion: Nasopharyngeal carcinoma due to holidays and other factors to extend the total duration of treatment, the local control rate and 3-year, 5-year survival rates will decline. Interruption of radiotherapy after the dose of the maximum 36 Gy, the effect of more significant impact. Replenishment group was significantly better than non-supplement group.