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With the development of life science, there is a growing requirement for high sensitive detection technologies in analysis. Fluorescence label is a convenient method. Indocyanines with larger extinction coefficients (105L/mol· cm), good fluorescent properties and fluorescence enhancement combining with biomass have been used as a new generation of fluorescent label compounds in biological analysis. However, photostability of these dyes has been a problem. In this paper the substituents on the nitrogen atoms in the heterocyclic rings of these indocyanines were designed as p-carboxybenzyl groups, and series novel straight chain polymethine indocyanines were synthesized. Introduction of rigid rings into the methine chain resulted in other series novel 3H-indocyanines.