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E-钙粘附蛋白（epithelialcadherin，E－cad）是一种跨膜糖蛋白的同质同嗜粘附分子，集中表达于粘着连接（adherensjunctions），维持上皮细胞的极性、形态和组织结构。我们运用SP免疫组化方法检测E－cad在大肠腺癌中的表达，探讨其与癌的分化程度、局部浸润深度、淋巴结转移和
E-cadherin (E-cad) is a homo-adhesion molecule of transmembrane glycoprotein, which is mainly expressed in adherence junctions and maintains the polarity, morphology and tissue structure of epithelial cells. We used SP immunohistochemistry to detect the expression of E-cadherin in colorectal adenocarcinoma and explore its differentiation with carcinoma, depth of local invasion, lymph node metastasis and