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子宫内膜容受性(ER)的建立是妊娠的关键性前提。ER的降低是不孕症的主要因素之一。HOXA10基因近年来被认为在ER的建立过程中具有重要意义,子宫内膜HOXA10表达增加是内膜具有良好容受性的必要条件,与胚胎着床密切相关,目前已将HOXA10作为ER建立的标志物之一。本文旨在对于子宫内膜异位症(EMS)、多囊卵巢综合征(PCOS)、输卵管积水及控制性超促排卵(COH)治疗不孕症患者的HOXA10基因是否存在异常表达的相关研究进展进行综述,希望能为治疗相关不孕症提供新的思路。
The establishment of endometrial receptivity (ER) is a key prerequisite for pregnancy. ER reduction is one of the main factors of infertility. In recent years, HOXA10 gene is considered to be of great significance in the establishment of ER. The increase of endometrial HOXA10 expression is a necessary condition for good endometrial acceptability, which is closely related to embryo implantation. At present HOXA10 has been established as a marker of ER One of the things. This article aims to investigate whether HOXA10 gene is abnormally expressed in endometriosis (EMS), polycystic ovary syndrome (PCOS), hydrosalpinx and controlled ovarian hyperstimulation (COH) The progress is summarized, hoping to provide new ideas for the treatment of infertility.