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目的:观察艾盒灸神阙佐治轻中度溃疡性结肠炎(脾虚证)的临床疗效及对血沉(ESR)、血小板计数(BPC),D-二聚体高凝状态的影响。方法:将63例脾虚证轻、中度活动性溃疡性结肠炎患者随机分为2组,对照组予柳氮磺胺吡定肠溶片(SASP)、双歧三联活菌胶囊口服的同时予甲硝唑氯化钠加入SASP、锡类散保留灌肠治疗。治疗组在对照组治疗方案的基础上给予艾盒灸神阙辅助治疗,比较2组临床疗效、Sutherland疾病活动指数评分标准(DAI)、肠镜积分及CRP、ESR、BPC、D-二聚体4项主要指标的变化。结果:总有效率治疗组93.94%,对照组73.33%,2组总有效率比较,差异有统计学意义(P<0.05)。2组治疗前后DAI、肠镜积分均较前下降,差异均有统计学意义(P<0.01);治疗后,治疗组DAI、肠镜积分低于对照组,差异均有统计学意义(P<0.05)。2组治疗后CRP、ESR、BPC、D-二聚体均下降,差异均有统计学意义(P<0.01);治疗后,治疗组CRP、ESR、BPC、D-二聚体改善程度优于对照组,差异均有统计学意义(P<0.05)。结论:艾盒灸神阙是轻、中度脾虚证溃疡性结肠炎有效、安全的佐治方法,治疗组在对临床疗效、DAI、肠镜积分以及高凝状态的改善方面均优于对照组。
Objective: To observe the clinical curative effect of Aiqitongxue Shenquezuo mild to moderate ulcerative colitis (spleen deficiency syndrome) and its effect on erythrocyte sedimentation rate (ESR), platelet count (BPC) and D-dimer hypercoagulability. Methods: Sixty-three patients with mild and moderate active ulcerative colitis with spleen Deficiency Syndrome were randomly divided into two groups. In the control group, SASP and Bifidobacterium tripterygii oral Nitidine chloride sodium added SASP, tin-type retention enema treatment. On the basis of the control group, the patients in the treatment group were treated with Auxiliary moxibustion and Shenque adjuvant therapy. The clinical efficacy, Sutherland disease activity index score (DAI), colonoscopy score and CRP, ESR, BPC and D-dimer Four major indicators of change. Results: The total effective rate was 93.94% in the treatment group and 73.33% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). The DAI and colonoscopy scores before and after treatment in both groups were significantly lower than those before treatment (P <0.01). After treatment, the scores of DAI and colonoscopy in the treatment group were lower than those in the control group (P < 0.05). The CRP, ESR, BPC and D-dimer in both groups decreased after treatment, the difference was statistically significant (P <0.01). After treatment, the improvement of CRP, ESR, BPC and D-dimer in the treatment group was better than that in the treatment group Control group, the difference was statistically significant (P <0.05). Conclusion: Acupressure moxibustion Shen Que is an effective and safe adjuvant treatment of ulcerative colitis with mild and moderate spleen deficiency syndrome. The treatment group is better than the control group in improving clinical efficacy, DAI, colonoscopy score and hypercoagulability.