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目的探讨绒毛膜促性腺激素β亚单位(β-hCG)在子宫颈癌患者病变组织的表达。方法本实验共研究通过活检或刮除术收集的不同临床分期的92例子宫颈癌标本,其中79例为鳞癌,11例为腺瘤,2例原位癌,通过免疫过氧化酶实验技术应用β-hCG抗体,检测相应抗原在宫颈癌石蜡包埋切片中的表达。结果77%(69/90)的宫颈癌患者βhCG抗体表达为阳性,鳞癌阳性例数80%(63/79)明显多于腺癌55%(6/11),β-hCG抗体在宫颈癌晚期患者表达阳性率明显高于早期患者(71%和29%)。结论产生β-hCG的肿瘤预后较差。
Objective To investigate the expression of human chorionic gonadotropin subunit β-hCG in diseased tissues of patients with cervical cancer. Methods A total of 92 cervical cancer specimens of different clinical stages collected by biopsy or curettage were studied. Among them, 79 were squamous cell carcinoma, 11 adenoma and 2 carcinoma in situ. Immuno-peroxidase assay β-hCG antibody to detect the corresponding antigen in cervical cancer paraffin-embedded sections. Results βhCG antibody was positive in 77% (69/90) of cervical cancer patients, and the positive rate of squamous cell carcinoma was significantly higher than that of adenocarcinoma (80%, 63/79) (55%, 6/11) The positive expression rate of patients with advanced stage was significantly higher than that of early stage patients (71% and 29%). Conclusion β-hCG tumors have poor prognosis.