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目的比较预混胰岛素类似物(优泌乐50)和预混人胰岛素(优泌林30R)治疗口服磺脲类降糖药继发失效的2型糖尿病的疗效。方法本研究为持续12周的随机、开放实验,48例口服降糖药继发失效的2型糖尿病患者随机分为优泌乐50治疗组和优泌林30R治疗组,治疗12周,观察两种不同治疗方法患者糖化血红蛋白(HbA1c)、空腹血糖、餐后2h血糖、低血糖发生率、胰岛素用量的差异。结果显示接受优泌乐50治疗组餐后2h血糖控制好于优泌林30R治疗组(P<0.01～0.05);优泌乐50治疗组胰岛素用量更少(P<0.05),糖化血红蛋白、空腹血糖两组差异无统计学意义(P>0.05);低血糖发生率优泌乐50治疗组较优泌林30R组发生率低。结论优泌乐50治疗2型糖尿病控制餐后血糖优于优泌林30R,低血糖发生率低于优泌林30R,同等疗效,优泌乐50治疗组更节省胰岛素。
Objectives To compare the efficacy of premixed insulin analogues (Ucrets 50) and premixed insulin (Uroem 30R) in the treatment of type 2 diabetes mellitus secondary to failure of oral sulfonylureas. Methods In this study, a randomized, open trial lasting for 12 weeks, 48 patients with type 2 diabetes mellitus who had secondary failure of oral hypoglycemic agents were randomly divided into Uehara 50 and Uroem 30R treatment groups for 12 weeks. HbA1c, fasting blood glucose, postprandial blood glucose 2h, incidence of hypoglycemia and insulin dosage in different kinds of treatment were compared. The results showed that the blood glucose level of 2 groups treated with Urged 50 was better than that of 30mL treated with Urogelin 30R (P <0.01 ~ 0.05), that of Urged 50 was lower (P <0.05), glycosylated hemoglobin, fasting There was no significant difference between the two groups in blood glucose (P> 0.05). The incidence of hypoglycemia was lower in Hurray 50-treated group than that in 30R group. Conclusion Youji 50 in the treatment of type 2 diabetes mellitus postprandial blood glucose control is superior to Youguilin 30R, the incidence of hypoglycemia is lower than 30uroproxylamine, the same effect, ugolic 50 treatment group more save insulin.