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目的对卵巢上皮性肿瘤组织中Bub1蛋白表达以及临床意义进行评价分析,为今后的临床诊治工作提供可靠的参考依据。方法抽取在2010年1月-2012年12月本院收治的卵巢良性肿瘤、卵巢交界性浆液性瘤、卵巢癌患者个30例,另抽取同期健康体检者30例,取所有研究对象卵巢组织,展开Bub1蛋白表达水平检测,并对比分析检测结果。结果卵巢交界性浆液性瘤、卵巢癌患者的卵巢组织中Bub1蛋白阳性表达率较健康者和卵巢良性肿瘤者高(P<0.05)。结论在卵巢交界性浆液性瘤、卵巢癌组织中Bub1蛋白出现高表达,这对于临床诊断和病情评估具有重要意义,值得关注。
Objective To evaluate the expression and clinical significance of Bub1 protein in ovarian epithelial tumor tissues and provide a reliable reference for future clinical diagnosis and treatment. Methods Thirty patients with benign ovarian tumors, borderline serous ovarian tumors and ovarian cancer admitted from January 2010 to December 2012 in our hospital were enrolled. Thirty patients with the same period of healthy physical examination were enrolled in this study. All the ovarian tissues, Expand Bub1 protein expression level detection, and comparative analysis of test results. Results The positive rate of Bub1 protein in ovarian borderline serous ovarian cancer patients and ovarian cancer patients was higher than that in healthy and ovarian benign tumors (P <0.05). Conclusion Bub1 protein is highly expressed in borderline serous tumors and ovarian cancers, which is of great importance for clinical diagnosis and disease evaluation.