双硫仑样反应指应用药物后,再饮酒导致的体内“乙醛蓄积”的中毒反应,表现为心悸、胸闷、全身潮红、头痛、恶心、呕吐等症状,甚至血压下降,乃至休克[1]。常发生双硫仑样不良反应的药物包括头孢哌酮、头孢曲松等头孢菌素以及甲硝唑、奥硝唑等咪唑类衍生物[2]。目前在临床上使用头孢菌素类药物与酒精所产生的双硫仑样反应已经引起广大医生 Disulfiram-like response refers to the application of drugs, and then caused by alcohol consumption in vivo “acetaldehyde accumulation” poisoning, manifested as palpitations, chest tightness, body flushing, headache, nausea, vomiting and other symptoms, and even blood pressure, and even shock [ 1]. Often occur disulfiram-like adverse drug drugs include cefoperazone, ceftriaxone and other cephalosporins and metronidazole, ornidazole and other imidazole derivatives [2]. Currently in the clinical use of cephalosporin drugs and alcohol produced by the disulfiram-like reaction has been caused by the majority of doctors