对西藏拉萨地区 2 4 3例成人“乙肝易感者”接种了乙肝疫苗 ,进行 3年随访。结果 :不同性别、不同民族间ＨＢｓＡｂ阳转率差异无显著性 ,第 ( 1～ 3)年总保护率分别为 95 .9%、95 .5 %和 92 .2 % ,第 3年开始下降。其间应重视的问题有 :进一步研究接种疫苗后无反应的问题 ;提高 Hepatitis B vaccine was given to 2 43 adult “hepatitis B susceptible persons” in Lhasa, Tibet for 3 years. Results: There was no significant difference in HBsAb positive rate among different nationalities and ethnic groups. The total protection rates in the first (1-3) years were 95.9%, 95.5% and 92.2% respectively, and decreased in the third year. Among the issues that should be emphasized are: Further research on the problem of non-responsiveness after vaccination;